Cytochrome P4502E1 and Other Xenobiotics Metabolizing Isoforms in Pathogenesis of Male Reproductive Disorders

Cytochrome P4502E1 and Other Xenobiotics Metabolizing Isoforms in Pathogenesis of Male Reproductive Disorders

Last decades investigations demonstrated significant decreasing of men fertility and sperm quality. Approximately, 50% clinically confirmed infertility cases are attributed to the male partners. Male infertility pathogenesis is investigated insufficiently; its direct interrelation with such pathologies as varicocele or urogenital infections was demonstrated only in 23% of cases. At present, it is supposed that different etiologic factors (including idiopathic) could start similar processes, which final result would be spermatozoids quality, and/or quantity decreasing. The present review discusses possible impact of cytochrome P-450 xenobiotics modulation effects directly in male reproductive organs, suggesting it as one of the mechanisms of subfertility development.