Creutzfeldt-Jakob Disease Susceptibility: An Approach to Discovering Multiple Candidate Genes for Human Prion Diseases

Creutzfeldt-Jakob Disease Susceptibility: An Approach to Discovering Multiple Candidate Genes for Human Prion Diseases

Human prion diseases, including Creutzfeldt-Jakob disease (CJD), the most common human prion disease, are fatal neurodegenerative disorders. They are characterized by the accumulation of an abnormal prion protein (PrPSc), vacuolation, astrocytic gliosis and neuronal cell loss in the brain