Comparison of Adenosine Deaminase (ADA) and Antigen 125 (CA-125) Level in Patients with Colon Cancer and Healthy Control

Aim: Colorectal cancer is the third common cancer in the world. This cancer develops slowly and silently so it is usually detected very late. Finding some simple methods for early diagnosis can lead to timely prevention and treatment of the cancer. Molecular biomarkers are factors that assessing their roles in diagnosis, prognosis and follow up different diseases especially cancers have got a lot of attention in recent years. CA-125 and ADA are two proteins that their increases have been observed in various cancers. In this study we want to compare ADA and CA-125 level in colorectal cancer patients and healthy controls.

Methods: 50 blood samples from patients and 50 samples from healthy control were obtained and ADA and CA-125 were assessed in both groups. ADA level was assessed using enzymatic method by auto analyzer (BT3000). CA-125 was measured by Eleusis based on chemiluminescence. Data was analyzed by SPSS 16 software.

Results: The mean level of ADA in patients group was 36.57 ± 1.5 U/L. Its level was 12.83 ± 5.7 U/L in control group. The average value of CA-125 in patients and healthy control were 63.54 U/ml and 15.67 U/ml, respectively.

Conclusion: Based on obtained results, ADA level was increased significantly compared to control group. (P<0.05) Although serum CA-125 level showed no notable differences.