Comparative Modeling of Serotonin Receptors 5ht2a and 5ht2c and In-silico Investigation of their Potential as Off-Target to Ethinylestradiol

Comparative Modeling of Serotonin Receptors 5ht2a and 5ht2c and In-silico Investigation of their Potential as Off-Target to Ethinylestradiol

The side effects of contraceptives in general and combined oral contraceptives in particular are numerous and are limiting factors in many cases leading to cease their use. At the same time the combined oral contraceptives or synthetic estrogens are increasingly being used in Medicine today. Several studies have addressed estrogen – serotonin interaction and it has been found that estrogen through its own receptors affect serotonin`s function. Here we hypothesized that synthetic estrogen may affect serotonin function by binding to serotonin receptors as off-target ones; therefore manipulate its function and further on explaining the mechanism by which side effects resulting from the use of synthetic estrogen (ethinylestradiol) take place.