Applications of Chemical Proteomics in New Drug Target Profiling

A critical need for novel drug targets has arisen as a result of the expanding demand for new treatment techniques in the medical and pharmaceutical domains. Contrarily, the targets of several medications that are currently commonly used in clinical practise have not been extensively documented. An integrated deconvolution of drug-target interactions is required for each drug since understanding a drug’s interactions with biological components is essential for understanding the pharmacologic effects of that medication. An effective mass spectrometry (MS)- based affinity chromatography method for finding proteome-wide small molecule-protein interactions and linking these interactions to signalling and metabolic pathways is the developing discipline of chemical proteomics.