An Emerging Role of MrgC in Inhibiting Neuropathic Pain

An Emerging Role of MrgC in Inhibiting Neuropathic Pain

The treatment of nonmalignant neuropathic pain continues to challenge clinicians owing to the limited efficacy of available treatments, dose-limiting adverse effects of drugs that are available, and lack of pain-specific treatment targets. G protein-coupled receptors (GPCRs) have been used frequently as drug targets for a variety of pharmacotherapies, including those for pathological pain. One novel family of GPCRs, the so-called Mas-related G protein-coupled receptors (Mrgs) may play a role in the function of nociceptive neurons as well as in sensation and modulation of pain.