Aluminum Phosphide (ALP) Poisoning a Challenge in Developing Countries. Symptom, Diagnosis and Treatment Strategies

Accidental or intentional poisoning by insecticides and rodenticide is a serious challenge. One of the most important of these toxins is aluminum phosphide(ALP), which is of great concern in developing countries. The main mechanism of toxicity of this substance is expressed in the form of inhibition of the electron transfer chain in mitochondria, which increases lipid peroxidation, decreases GSH and thus reduces ATP production. A range of symptoms for mild to severe AlP poisoning have been reported, with the leading cause of death in patients with Cardiovascular and respiratory disorders. The diagnostic aspect of poisoning is mostly based on the patient's history, self-expression, and clinical symptoms.