Acute Liver Failure to Fluoxetine Therapy

The drug induced liver injury by antidepressant is being reported in the literature nowadays. However fluoxetine induced hepatotoxicity has not been well recognized. Usually asymptomatic increase in liver enzymes has been reported in 0.5% of the patient who are taking this drug for long-term therapy. The exact mechanism is still unknown however treatment approach is usually very conservative. Here we discuss a case of hepatic failure secondary to short term Fluoxetine therapy which is very rarely reported in the literature.