Extent and Severity of Coronary Artery Disease as Predictors of Myocardial Reperfusion in Acute Coronary Syndrome

Background: Worldwide, Coronary Artery Disease (CAD) is the single most frequent cause of death. Over seven million people every year die from CAD, accounting for 12.8% of all deaths. Every sixth man and every seventh woman in Europe die from Myocardial Infarction (MI). Objectives: To assess the extent and severity of coronary artery disease as predictors of myocardial reperfusion in acute coronary syndrome. Patients and Methods: A prospective cohort study included patients admitted with Acute coronary syndrome after approval from the Research and Ethics Committee of Faculty of Medicine, Menofeya University from January 2015 to January 2020. They divided into two groups: Group (I): included patients with ST Elevation Myocardial Infarction (STEMI) in whom primary Percutaneous Coronary Intervention (PCI) done or pharmacoinvasive therapy either total or subtotal revascularization. Group (II): included patients with Non-ST Segment Elevation Myocardial Infarction (NSTEMI and UA) in whom PCI done either total or subtotal revascularization. Results: The cutoff value of Troponin, CK and CKMB in prediction of myocardial reperfusion in acute coronary syndrome. Our ROC results revealed that Troponin, CK and CKMB cutoff value is greater than 20, 440, and 50 and the area under the ROC curve is equal to 0.796, 0.732 and 0.690 which indicating that they are fair predictors for myocardial reperfusion in acute coronary syndrome. The sensitivity values of Troponin, CK, and CKMB were 78.2, 77.3 and 70 respectively and the specificity values of Troponin, CK and CKMB were 66.4, 65.7 and 64.3 respectively. Conclusion: Our study indicated that there is a significant Association between both syntax score and extent of CAD and Myocardial perfusion.