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Hindi Short Communication, J Forensic Toxicol Pharmacol Vol: 3 Issue: 4
A �Theoretical� Postmortem Redistribution Factor (Ft) as a Marker of Postmortem Redistribution
| McIntyre Iain M* | |
| Forensic Toxicology Laboratory Manager, County of San Diego Medical Examiner’s Office, 5570 Overland Ave, San Diego, USA | |
| Corresponding author : Iain M McIntyre Forensic Toxicology Laboratory Manager, County of San Diego Medical Examiner’s Office, 5570 Overland Ave, Suite 101, CA 92123, San Diego, USA Tel: +858 694-2907 E-mail: Iain.McIntyre@sdcounty.ca.gov |
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| Received: August 18, 2014 Accepted: October 25, 2014 Published: October 28, 2014 | |
| Citation: McIntyre IM (2014) A “Theoretical” Postmortem Redistribution Factor (Ft) as a Marker of Postmortem Redistribution. J Forensic Toxicol Pharmacol 3:3. doi:10.4172/2325-9841.1000131 |
Abstract
A “Theoretical” Postmortem Redistribution Factor (Ft) as a Marker of Postmortem Redistribution
Postmortem redistribution (PMR) refers to the changes that can occur in drug concentrations after death. Literature supports a model describing drugs with a liver (L) to peripheral blood (P) concentration (L/P) ratio less than 5 L/kg as being prone to little or no PMR, while drugs with an L/P ratio greater than 20-30 L/kg have propensity for substantial PMR. Additionally, the concept of a post-mortem redistribution (F) factor has been recently described to express the direct relationship between post mortem peripheral blood and the corresponding antemortem whole-blood concentration. The current document expounds upon both these concepts by proposing the development of a “theoretical” postmortem redistribution factor (Ft) for a drug––based upon a drug’s characteristic L/P ratio. This model for estimating potential of PMR was produced to assist with a credible interpretation of postmortem drug concentrations.
