Research Article, Cell Biol Res Ther Vol: 4 Issue: 2
Preventive Effects of Methanolic Extract of Seeds of Nigella sativa Linn. on PMA Induced Apoptosis in Human Blood Lymphocytess
| Yamani B Tripathi* and Nidhi Pandey |
| Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India |
| Corresponding author : Yamani B Tripathi Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India Tel: 9415694450 E-mail: yaminiok@yahoo.com |
| Received: February 03, 2015 Accepted: June 08, 2015 Published: June 15, 2015 |
| Citation: Tripathi YB, Pandey N (2015) Preventive Effects of Methanolic Extract of Seeds of Nigella sativa Linn. on PMA Induced Apoptosis in Human Blood Lymphocytes. Cell Biol: Res Ther 4:1. doi:10.4172/2324-9293.1000117 |
Abstract
Although radiation therapy is widely used for cancer-treatment but it is associated with several side effects. It involves free radical/PKC mediated pathway to induce DNA damage and apoptosis in target cells. The tyrosine kinase inhibitors, antioxidants and PKC inhibitors have been reported to be radio-protective. However, new radio-protector, especially from herbal origin is always in demand, as they have comparatively lesser side effects, because of their natural origin.
