Research Article, J Vet Sci Med Diagn Vol: 5 Issue: 1
Systemic Amyloid A Amyloidosis in a Dog with Sub-acute Time Course after Anesthesia
| Miyake A1, Tsukawaki T1, Matsuda Y2, Kishimoto M2, Murakami T1 and Suzuki K1* | |
| 1Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Tokyo, Japan | |
| 2Laboratory of Veterinary Diagnostic Imaging, Tokyo University of Agriculture and Technology, Tokyo, Japan | |
| Corresponding author : Kazuhiko Suzuki Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan Tel: +81-42-367-5689 E-mail: kzsuzuki@cc.tuat.ac.jp |
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| Received: January 18, 2016 Accepted: February 16, 2016 Published: February 23, 2016 | |
| Citation: Miyake A, Tsukawaki T, Matsuda Y, Kishimoto M Murakami T, et al. (2016) Systemic Amyloid A Amyloidosis in a Dog with Sub-acute Time Course after Anesthesia. J Vet Sci Med Diagn 5:1. doi:10.4172/2325-9590.1000187 |
Abstract
Systemic Amyloid A Amyloidosis in a Dog with Sub-acute Time Course after Anesthesia
An 8-year-old female beagle used for investigation of diagnostic imaging rapidly became ill without premonitory symptoms the day after undergoing anesthesia and died about 2 months later. Systemic amyloidosis was found by necropsy, and severe amyloid deposition was observed in the pancreas, kidney and spleen. Immunohistochemically, almost all amyloid depositions comprised amyloid A. Other findings included thrombi in the pulmonary artery and aorta and plasma cell infiltration in multiple organs, including the kidneys. Amyloid A amyloidosis is the most common type of amyloidosis in animals and occurs in association with chronic inflammation and neoplasia. However, the sub-acute course in the present case is rare and suggests an association between anesthesia and thrombi without clear background lesions.
