Research Article, Cell Biol Res Ther Vol: 4 Issue: 1
Modulation of Neurobehavioral and Biochemical Alterations Induced by Aluminum Chloride with Cannabis sativa Extract
| Omar ME Abdel-Salam1*, Marawa El-Sayed El-Shamarka1 and Enayat A Omara2 | |
| 1Department of Toxicology and Narcotics and Pathology, National Research Centre, Cairo, Egypt | |
| 2Department of Pathology, National Research Centre, Cairo, Egypt | |
| Corresponding author : Omar M.E. Abdel Salam Department of Toxicology and Narcotics, National Research Centre, Tahrir St., Dokki, Cairo, Egypt Tel : +2-0 2-33335996 E-mail: omasalam@hotmail.com. |
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| Received: November 22, 2014 Accepted: April 16, 2015 Published: April 23, 2015 | |
| Citation: Abdel-Salam OM, El-Shamarka MES, Omara EA (2015) Modulation of Neurobehavioral and Biochemical Alterations Induced by Aluminum Chloride with Cannabis sativa Extract. Cell Biol: Res Ther 4:1. doi:10.4172/2324-9293.1000114 |
Abstract
Cannabis sativa preparations in the form of marijuana (the dried flowering tops and leaves) and hashish (the dried resin and compressed flowers) from the female plant Cannabis sativa is the most widely used illicit drugs worldwide. In humans, cannabis is associated with a spectrum of central nervous system effects. These include euphoria, relaxation and perceptual alterations, which are mediated by Δ9-tetrahydrocannabinol (Δ9-THC) the primary psychoactive constituent of cannabis. Other cannabinoids include cannabinol, cannabidiol, cannabigerol, cannabichromene, and cannabidivarin. Cannabinoid CB1 receptors have been cloned and identified in high concentration in several brain regions eg., hippocampus, basal ganglia, cerebellum and cerebral cortex.
