The Journal of Virology & Antiviral Research (JVA) promotes rigorous research that makes a significant contribution in advancing knowledge for Microbiology and Medicine. The journal includes all major themes pertaining to viral diseases and treatment.
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Prevention of Cervical Cancer in Women: Human Papillomavirus DNA Testing in Atypical Pap Smears
Human papillomavirus (HPV) is definitely recognized as the necessary cause for the development of cancer of the uterine cervix and the detection of HPV-DNA in cervical samples is demonstrated to own a significantly higher sensitivity towards preneoplastic lesions than conventional cytology (Pap test). Screening, management of atypical Pap tests and follow up of treated patients, represent the optimal settings where HPV-DNA testing has been demonstrated of clinical value. Atypical Pap tests account for cases in which the cytological alterations cannot clearly be attributed neither to negative nor to positive cytology; in these cases HPV-DNA testing has been demonstrated to have a sensitivity very close to 100% in identifying patients with an histologically proven intraepithelial preneoplastic lesion of high grade (CIN2-CIN3).
HIV Treatment with Once-Daily Single Tablet Regimens
Treatment for HIV infections requires lifelong antiretroviral therapy. Patient compliance with treatment is therefore very important in the context of effective viral suppression and avoiding the development of drug resistance. Until the last decade, there was a lack of efficient single tablet regimens (STRs).
Antigenic Complementarity between Influenza A Virus and Haemophilus influenzae may Drive Lethal Co-Infection Such as that Seen in 1918-19 Pandemic
Pfeiffer’s bacillus, now known as Haemophilus influenzae (HI), was strongly implicated in the high lethality of the 1918-19 influenza pandemic. Influenza virus (IV) infection is often complicated by (HI) super-infection and certainly was so in 1918-19. We propose that the influenza pandemic of 1918-19 was caused by concurrent pandemics of IV and HI that overwhelmed co-infected individuals through antigenic synergy between the two infections. Using T cell receptor sequences specific for IV and HI antigens, we demonstrate that IV and HI antigens induce molecularly complementary TCR responses.
HIV/AIDS in Africa: Trends, Missing Links and the Way Forward
Within the African regions, there are striking differences in human immunodeficiency virus (HIV) disease burden yet social and cultural differences are relatively small suggesting that sexual transmission alone may not explain HIV infections in Sub-Saharan Africa (SSA). Thus, sexual contact with an infected person represents only a necessary, but not sufficient, condition for HIV transmission through sex.