The University of Texas MD Anderson Cancer Center, USA
The Journal of Regenerative Medicine (JRGM) promotes rigorous research that makes a significant contribution in advancing knowledge for developing new therapeutic approaches to prevent and treat life-threatening diseases. JRGM includes all major themes pertaining to regenerative medicine therapies, applications in stem cell and tissue engineering.
Regenerative Medicine is a subscription based journal that provides a range of options to purchase our articles and also permits unlimited Internet Access to complete Journal content. It accepts research, review papers, online letters to the editors & brief comments on previously published articles or other relevant findings in SciTechnol. Articles submitted by authors are evaluated by a group of peer review experts in the field and ensures that the published articles are of high quality, reflect solid scholarship in their fields, and that the information they contain is accurate and reliable.
Tissue Engineering Approaches for Motor Neuron Pathway Regeneration
During fetal development, a tightly-regulated spatio-temporal pattern of guidance cues directs and maintains motor neuron axonal growth along specific pathways to reach the target cells and tissues. However, an inflammatory environment resulting from an injury (e.g., trauma, stroke) or disease [e.g., amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), and hereditary spastic paraplegia (HSP)] leads to progressive degeneration of motor neurons and destruction of axonal tracts in the adult CNS.
Nobel Prize to Inducent Pluripotent Stem Cells and Cloning: A Milestone for the Regenerative Medicine
Sir John B. Gurdon from United Kingdom and Shinya Yamanaka from Japan are winners of the 2012 Nobel Prize in Physiology or Medicine for their work on induced pluripotent stem cells (iPS) and cloning. Shinya Yamanaka (Center for iPS Cell Research and Application, Kyoto University, Japan) wins the prize for figuring out how to develop induced pluripotent stem cells. These cells can be reprogrammed into completely different kinds.
Human Stem Cell Derivatives Retain More Open Epigenomic Landscape When Derived from Pluripotent Cells than from Tissues
The ability of a stem cell both to self-renew and differentiate into desired phenotypes makes it a potentially inexhaustible cell source for tissue and functional restoration. Discerning the complex identities of human stem cell derivatives from various developmental stages and sources is essential for selection of an optimally lineage-committed human stem cell with sufficient plasticity along the fate restriction continuum to address a particular disease.