The Journal of Forensic Toxicology and Pharmacology (JFTP) promotes rigorous research that makes a significant contribution in advancing knowledge of variations in biochemical functions and detailed information on forensic studies. The JFTP includes all major themes pertaining to forensic toxicology and pharmacology.
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Different preparations of Cannabis sativa (commonly marijuana and hashish) are widely used mainly for their euphoric effects. Cannabis after alcohol consumption is by far the most commonly used recreational drug in Europe. About 20% of adults in the European Union (aged 15–64 years), over 62 million people, have tried cannabis at least once in their life [1]. Users and lay people believe that marijuana or hashish is safe. Many cases of cardiovascular events have, however, been related to a cannabis consumption [2-4], and cases of acute ischemia or thrombosis even on the ground of normal coronary arteries have been reported.
Fighting the War on Drugs: What Weapons for Analysis and Detection?
The abuse of drugs has become one of the most serious socialproblems in the world. According to the “United Nations Office on Drugs and Crime” (UNODC) latest report, between 149 and 272 million people used illicit substances at least once in the year 2008.The world population of “Problem drug users”, defined as regular users of illicit substances is estimated at between 15 and 39 million. Amphetamines, cocaine, opiates and cannabis are the most abused substances. In addition non-medical use of prescription drugs is reportedly a growing health problem in a number of developed and developing countries.
Solid Phase Extraction and Analysis of THC and Metabolites from Whole Blood using a Novel Automated Procedure using Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS)
In this study, solid phase extraction (SPE) is described using a novel automated procedure to isolate tetrahydrocannabininol and its metabolites from whole blood samples. SPE was performed on an automated system after samples of whole blood were precipitated with acetonitrile. The system was programmed to condition the SPE columns with methylene chloride, methanol,de-ionized (DI) water, and aqueous phosphate buffer (0.1 M pH 7). The samples were loaded by the robot after which the SPE columns were washed with DI water, aqueous phosphate buffer and dried also by the same unit.
