The Journal Analgesia & Resuscitation : Current Research (ARCR) promotes a significant contribution in advancing knowledge about acute care medicine and resuscitation. ARCR includes all major themes pertaining to analgesic drugs and mode of action, resuscitation procedures.
Analgesia & Resuscitation : Current Research is a subscription based journal that provides a range of options to purchase our articles and also permits unlimited Internet Access to complete Journal content. It accepts research, review papers, online letters to the editors & brief comments on previously published articles or other relevant findings in SciTechnol. Articles submitted by authors are evaluated by a group of peer review experts in the field and ensures that the published articles are of high quality, reflect solid scholarship in their fields, and that the information they contain is accurate and reliable.
Is Compartment Syndrome Risk a Contraindication to Regional Analgesia?
Acute compartment syndrome (ACS) occurs when pressure within a closed space causes ischemia to the tissues within that space. It is relatively rare, with an incidence of 3.1 per 100,000, but it can be devastating if not promptly diagnosed and treated. The diagnosis of compartment syndrome is a clinical one, based primarily on the presence of pain out of proportion to the clinical situation, often worsened by muscle stretch. Based on a few case reports and case series, some, particularly in the orthopedic community, have suggested that regional anesthesia should be avoided in patients at risk for ACS. This is based on a concern that the analgesia from regional anesthesia may mask the hallmark sign of ACS, pain.
An Emerging Role of MrgC in Inhibiting Neuropathic Pain
The treatment of nonmalignant neuropathic pain continues to challenge clinicians owing to the limited efficacy of available treatments, dose-limiting adverse effects of drugs that are available, and lack of pain-specific treatment targets. G protein-coupled receptors (GPCRs) have been used frequently as drug targets for a variety of pharmacotherapies, including those for pathological pain. One novel family of GPCRs, the so-called Mas-related G protein-coupled receptors (Mrgs) may play a role in the function of nociceptive neurons as well as in sensation and modulation of pain.
Prospective Study of Intrathecal Morphine versus Patient Controlled Analgesia in Cardiac Patients
Median sternotomy, the most common access used for cardiac surgery, is usually associated with severe early postoperative pain. Aggressive sternotomy pain control facilitates recovery, early mobilisation and decreases post-operative morbidity with direct implications for clinical resource utilisation and cost. Strategies to achieve effective early postoperative pain control after cardiac surgery have been reported to include; the use of opioids delivered as intravenous infusion, intravenous patient-controlled analgesia, epidural infusion, epidural patient-controlled analgesia, single intrathecal bolus, and intermittent subcutaneous boluses. Local anaesthetic agents have been injected into the surgical site, or thoracic epidural space as boluses and/or infusion.
Intravenously Administered Fentanyl is Not Detectable in Exhaled Breath
Relapse rates amongst anesthesia residents and CRNAs who were previously addicted to fentanyl, rehabilitated, and considered to be in stable recovery, are reported to be extremely high upon return to the operating room environment. Previous studies have proposed that there is a small amount of fentanyl in the exhalation limb of the anesthesia circuit when patients are given intravenous fentanyl, leading to a novel source of exposure for anesthesia providers and possible sensitization in predisposed individuals. However, prior studies have been limited by their small sample size and questionable study methodology. This study aimed to determine the quantity of fentanyl exhaled after intravenous fentanyl administration.